50th Anniversary MSTS Annual Meeting

A curated collection of peer-reviewed research abstracts. Explore the gallery, search by paper number or title, and open any full paper directly.

28–31 OctoberJW Marriott Turnberry Conference Center – Miami, Florida

Abstract Gallery

86 abstracts

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Paper 1

Poisoning the Clot: Dominant-Negative Fibrinogen Permits Osteosarcoma Metastasis

Stephen W. Chenard, MSc

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Paper 2

Age-Stratified Transcriptomic Profiling Reveals Biologically Distinct Molecular Phenotypes Across Pediatric, Adolescent, and Adult Osteosarcoma

David Geller, MD, MBA

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Paper 3

Neuropilin-2 as a Therapeutic Target in Osteosarcoma: Spatial Transcriptomics and In Vivo Testing of a Clinic-Ready Anti-Neuropilin-2 Antibody

Sung-Suk Chae, PhD

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Paper 4

PNKP Inhibition Demonstrates Selective Activity in PTEN-Deficient Osteosarcoma and Is Enhanced by NRF2 Blockade

Joseph Kendal, MD, FRCSC

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Paper 5

DNA methylation analysis of undifferentiated pleomorphic sarcoma of bone

Duncan C Ramsey, MD, MPH

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Paper 6

Evolution-Informed Extinction Therapy: A Novel Treatment Paradigm for Osteosarcoma

William Eward, MD, DVM

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Paper 7

Translational Evaluation of ALDH and MMP-9 Expression in Osteosarcoma: Insights into Chemotherapy Response and Survival from a Single-Center Cohort

Ana Valeria Rigolino Teixeira, MD

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Paper 8

Advanced Transcriptomic Analysis of Spp1 in Osteosarcoma: A potential new therapeutic target?

Sung-Suk Chae, PhD

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Paper 9

Immune Cell Composition and Chronic Inflammation Association in Primary High-Grade Osteosarcoma

Rosanna Wustrack, MD

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Paper 10

Evolving Toward Precision Oncology in Osteosarcoma

Zachary Burke, MD

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Paper 11

Pan-cancer Multi-Omics Identifies SKP2 as a Marker of Immune Exclusion with In Vivo Validation in Osteosarcoma

David Geller, MD, MBA

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Paper 12

Longitudinal Single-Cell Analysis of Osteosarcoma Defines Pre-treatment Chemoresistance and an Actionable PI3K Target

David Geller, MD, MBA

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Paper 13

Tumor-Mediated Fibrinolysis as a Mechanism and Therapeutic Target in Osteosarcoma Metastasis

Stephen Chenard. MSc

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Paper 14

Prognostic Role of TERT Mutations in Chondrosarcoma: Association with Dedifferentiated Tumors and Survival Outcomes

H. Thomas Temple, MD

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Paper 15

ASPH blockade abrogates doxorubicin induced chemoresistance in chondrosarcoma

Richard Terek, MD, FACS

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Paper 16

Targeting DNMT3B Reveals an Epigenetic Vulnerability in Chondrosarcoma

David Clever, MD

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Paper 17

Impact of Surgical Margins in Chest Wall Chondrosarcomas: A CanSaRCC Study

Aaron Gazendam, MD, FRCSC

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Paper 18

When an Intra-Articular Process Is More Than It Appears: Malignant Transformation of Synovial Chondromatosis to Chondrosarcoma

Julian Emerson Dilley, MD

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Paper 19

The tetravalent death receptor 5 (DR5) agonist ozekibart (INBRX-109) in conventional chondrosarcoma: secondary efficacy endpoints from the randomized, registrational, phase 2 ChonDRAgon study

Robin L. Jones, MD

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Paper 20

Does pain signal malignancy? Investigating the reliability of pain symptoms in predicting chondrosarcoma

Alexander Lazarides, MD

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Paper 21

EWSR1-FLI1-Associated Cohesin and DNA Damage Response Dependencies Identified by Pan-Cancer CRISPR Profiling in Ewing Sarcoma

Brandon Gettleman, MD

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Paper 22

Targeting Glutamine Metabolism to Enhance Radiosensitivity in Ewing Sarcoma

Brittany Simone, DO

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Paper 23

Characterization of the NK Regulatory Landscape in the Tumor Microenvironment of Pediatric Sarcomas

Adrian Ibanez Navarro, MD

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Paper 24

Beyond RECIST: Prognostic value of Soft-Tissue Volume Reduction in Ewing Sarcoma

Julian Emerson Dilley, MD

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Paper 25

Compression of Intercalary Allografts with Magnetic Lengthening Nails, Mid-term Results with a Comparison of Techniques

Lee Zuckerman, MD

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Paper 26

All internal distraction osteogenesis after tumor resection with magnetic intramedullary nails

Lee Zuckerman, MD

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Paper 27

Appositional bone growth is a risk for aseptic loosening following lower extremity endoprosthetic reconstruction in pediatric bone sarcoma patients

Michael Colello, MD

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Paper 28

Reverse Total Shoulder Arthroplasty Improves Function Compared to Hemiarthroplasty in Pediatric Proximal Humerus Tumor Reconstruction: A Multicenter Study

Spencer M. Richardson, MD

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Paper 29

True Infection Is Rare Despite Extensive Workup for Postoperative Fever After Pediatric Extremity Sarcoma Surgery

Rajul Gupta, MD

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Paper 30

Why the Rotationplasty Patient-Powered Registry Is Crucial for Shared Decision Making: "We need as much research as we can get!"

Janet E. Panoch, PhD

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Paper 31

Minimally Invasive Pelvic Fixation of Pelvic Metastases Using CT-Assisted Surgical Navigation is Associated with Predictable Pain Relief and Durable Restoration of Skeletal Stability and Function

Nicola Fabbri, MD

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Paper 32

Long-Term Functional Outcomes and Survival Following Intramedullary Nailing of Pathological Diaphyseal Tibial Fractures)

Sonia Ubong, MBBS

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Paper 33

No Difference in Medical or Surgical Complications after Long and Short Intramedullary Nail Fixation for Pathologic Pertrochanteric Femur Fractures.

Otitochukwu Ezeonu, MD

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Paper 34

Predictors of Survival After Prophylactic Femoral Fixation for Metastatic Bone Disease: Where You Live Matters

Brian Benyamini

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Paper 35

Construct Durability, Revision Burden, and Resource Use After Fixation Versus Endoprosthetic Reconstruction for Appendicular Metastatic Bone Disease

Christopher D Hamad, MD

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Paper 36

The Proximal Femur Reconstruction or Internal Fixation for Metastases (PERFORM) International Randomized Controlled Trial

Michelle Ghert, MD, FCSC

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Paper 37

Prophylactic eFLASH Pulmonary Radiation Inhibits Lung Metastases and Improves Survival in a Murine Soft-Tissue Sarcoma Metastatic Model

Vincent Y. Ng, MD

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Paper 38

Long-term outcomes of denosumab therapy and treatment discontinuation in patients with bone metastases

Atsushi Mihara, MD

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Paper 39

A Risk Stratification Tool Based on Inflammatory and Nutritional Biomarkers to Predict Early Mortality After Surgery for Appendicular Bone Metastases

Ana Valeria Rigolino Teixeira, MD

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Paper 40

PathFx vs modified Tokuhashi score for survival prediction in metastatic bone disease of the spine

Divakar N. Lal, MD

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Paper 41

Integrated Patient-Reported Outcomes and Passive Mobility Monitoring Following Metastatic Bone Disease Surgery: A Prospective Study of Feasibility and Early Recovery Patterns

Joseph Kendal, MD, FRCSC

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Paper 42

Central Nervous System Tropism in CIC-Rearranged Sarcoma: A Rationale for Upfront Screening

Aron Mebrahtu

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Paper 43

Impact of Radiation Therapy on Skeletal-Related Events in Renal Cell Carcinoma Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Cohort Study

Alan T. Blank, MD, MS

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Paper 44

Bone Metastases in Soft Tissue Sarcoma: Natural History, Prognostic Factors, and Genomic Characterization in a Modern Cohort

Madeline Rieker, MD

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Paper 45

3D-Printed Hemipelvic Endoprostheses Improve Long-term Function and Sacroiliac Stability after Enneking Type II/II+III Periacetabular Tumor Resection: A Matched Cohort Study

David Geller, MD, MBA

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Paper 46

Custom 3D-Printed Pelvic Reconstruction Versus No Implant Reconstruction Following Oncologic Periacetabular Resection: A Multi-Institutional Comparative Outcomes Study

Alexander Lazarides, MD

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Paper 47

Functional Recovery Trajectories Following Internal Hemipelvectomy: Custom 3D-Printed Reconstruction vs. Non-Reconstruction

William Eward, MD, DVM

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Paper 48

Sacral Chordoma Resection - Anterior Video-Assisted Laparoscopic Approach

EDUARDO SADAO YONAMINE, MD

Cover page of abstract Paper 49
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Paper 49

When a Recurrent Giant Cell Tumor of Bone Is Not the Same Tumor: Dedifferentiation with Previously Unreported Squamous Differentiation Highlighting Tumor Heterogeneity and the Need for Repeat Histologic Assessment.

Drew Ormseth, MD

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Paper 50

Progression of Fibrous Dysplasia to Low-Grade Central Osteosarcoma: Reassessing Tumor Biology When the Clinical Course Deviates.

Drew Ormseth, MD

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Paper 51

Immune Phenotype-Dependent Pembrolizumab Effects in High-Risk Localized Soft Tissue Sarcoma: A multimodal and explainable machine learning analysis of SARC032 trial data

Anthony Bozzo, MD, FRCSC

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Paper 52

AR for Sarcoma Surgery - the Future is Here

Ahmed Aoude, MD, FRCSC

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Paper 53

An End-to-End Deep Learning Framework and Multicenter Validation for the Diagnosis of Retroperitoneal Soft Tissue Sarcoma

Tong Meng, MD

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Paper 54

Augmented Reality Guidance for Targeted Re-Resection of Positive Margins in Sarcoma

Michael Colello, MD

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Paper 55

Preoperative Surgical Margin Assessment Using a Three-Dimensional-Printed Model for Simulated Surgery of Periarticular Malignant Bone Tumors

Shachar Kenan, MD

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Paper 56

Development and Optimization of In-Situ Local Tumor Ablation and Recycling System for Consistent Heating and Clinical Translation

Min Wook Joo, MD, PhD

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Paper 57

Sarcoma Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography

Mikaela Sullivan, MD

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Paper 58

Impact of Neoadjuvant Radiation on Pathogen Profiles and Cefazolin Coverage in Soft Tissue Sarcoma Resection

William Eward, MD, DVM

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Paper 59

Plantar Fibromatosis: Surgical Approach for a Tumor with a Tissue-Specific Propensity for Recurrence

William G Ward, MD, FACS

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Paper 60

An in vivo platform enables evaluable drug responses in patients with soft tissue sarcoma

Kenneth Gundle, MD

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Paper 61

The Surveillance After Extremity Tumor Surgery (SAFETY) International Randomized Controlled Trial

Michelle Ghert, MD, FCSC

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Paper 62

Quantitative Margin Assessment Predicts Local Recurrence in Myxofibrosarcoma

Jun Iwatsu, MD

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Paper 63

Beyond the Biopsy: High Rates of Grade and Diagnostic Discrepancy in Myxofibrosarcoma - A Single-Center Analysis

Paniz Eizadkhah

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Paper 64

Expanding Indications for Compress® Mega-prosthetic Reconstruction: Successful Management of High-Risk Patients (Age >50, Cortical Thickness <2.5 mm, or Pre-operative Smoking)

Jungo Imanishi, MD, PhD

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Paper 65

Multidisciplinary Collaboration in Chest Wall Surgery: Excellent Outcomes with a First of Its Kind Combined Orthopedic and Thoracic Team

Nathan W. Mesko, MD

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Paper 66

What Factors Are Associated with Instability After Endoprosthetic Reverse Total Shoulder Arthroplasty for Oncologic Reconstruction of the Proximal Humerus?

Alexander Lazarides, MD

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Paper 67

Adverse Events and Patient-Reported Outcomes with the Osseointegrated Prostheses for the Rehabilitation of Amputees (OPRA) Implant in Transfemoral Amputees

Melissa Zimel, MD

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Paper 68

A Nine-Year Experience with a New Fully Cemented, Hybrid, Splined, Porous-Coated Stem in Oncologic Reconstruction

Christopher Hamad, MD

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Paper 69

Why Revisions Fail? Risk Factors and Predictors of Reoperation Following Revision Megaprosthetic Reconstruction for Tumors Around the Knee

Taha Aksoy, MD

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Paper 70

Indocyanine Green Fluorescence for Intraoperative Margin Assessment in Musculoskeletal Tumor Surgery: A Single-Institution Experience

Sonia Ubong, MBBS

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Paper 71

From Scalpel to Slide: The Impact of Air Exposure and Histologic Processing on Surgical Margins

Christopher Collier, MD

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Paper 72

Oncological Indication Does Not Portend Worse Outcomes After Proximal Femoral Replacement: Prior Surgical Burden rather than Diagnosis, Drives Revision Risk

Stephen W. Chenard, MSc

Cover page of abstract Paper 73
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Paper 73

Diminished Remaining Subchondral Bone Predicts Risk for Fracture or Arthritis Following Treatment of Giant Cell Tumor of Bone at the Knee

Joseph Ippolito, MD

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Paper 74

Patterns and Timing of Local Recurrence in Benign Bone Tumors

Bradley Melvin

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Paper 75

Pimicotinib in tenosynovial giant call tumor (TGCT): Long-term efficacy, safety, and patient-reported outcomes from the Phase 3 MANEUVER trial

Vinod Ravi, MD

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Paper 76

MRI Characteristics to Differentiate Benign versus Malignant Bone Lesions

Ava Brozovich, MD

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Paper 77

Microbiologic Spectrum and Risk Factors for Surgical Site Infection Following Soft Tissue Sarcoma Resection

Aaron Gazendam, MD, FRCSC

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Paper 78

Comparing Early Outcomes of Antibacterial-coated vs Uncoated Endoprostheses: A Single Institution's Experience with Nanocept Technology

Danielle Rider, MD

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Paper 79

Risk Factors and Reconstructive Consequences of Infection After Proximal Humeral Endoprosthetic Reconstruction: A Multi-Institutional Study

Alexander Lazarides, MD

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Paper 80

Synovial Calprotectin Accurately Detects Periprosthetic Joint Infection in Tumor Megaprostheses: A Prospective Cohort Study

Panayiotis Gavriil, MD

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Paper 81

Distal Femoral Replacement for Oncologic Versus Non-Oncologic Indications: Comparative Outcomes and Predictors of Failure

Stephen Chenard, MSc

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Paper 82

Prospective Validation of Intraoperative ICGA Perfusion Thresholds for Predicting Wound Complications Following Resection of Preoperatively Irradiated Soft Tissue Sarcoma

Alexander Lazarides, MD

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Paper 83

Results of the first 700 patients treated with a one-stage revision for PJIs

Gerhard Maale, MD

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Paper 84

NexGen Sequencing (NGS) is more accurate than culture and sensitivity (CS) in PJIs

Gerhard Maale, MD

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Paper 85

Results of lymphocyte transformation testing in known cases of PJI

Gerhard Maale, MD

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Paper 86

Hydrolyzed Collagen Augmentation is Associated with Reduced Wound Complications Following Resection of Preoperatively Irradiated Extremity Soft Tissue Sarcomas

Alexander Lazarides, MD